GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119
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چکیده
منابع مشابه
GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119
Primary cilia are sensory organelles indispensable for organogenesis and tissue pattern formation. Ciliopathy small GTPase ARLs are proposed as prominent ciliary switches, which when disrupted result in dysfunctional cilia, yet how ARLs are activated remain elusive. Here, we discover a novel small GTPase functional module, which contains ARL-3, ARL-13, and UNC-119, localizes near the poorly und...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep24534